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HGH (Somatropin)

Also sold as Growth Hormone, Genotropin, Norditropin.

Half-life
3 h
Steady state
~1 d
Class
GH
Category
Peptide

Published population averages. Steady state is the usual five half-life rule of thumb, not a measurement. See peptide half-life, explained.

Overview

Recombinant Human Growth Hormone (rhGH/Somatropin) is a 191-amino acid protein identical to endogenous pituitary GH. It is FDA-approved for multiple conditions including pediatric and adult GH deficiency, Turner syndrome, and HIV-associated wasting. Off-label use in anti-aging and performance contexts is common but controversial.

How it works

Binds growth hormone receptors (GHR) on hepatocytes to stimulate IGF-1 production, which mediates most anabolic effects. Direct effects include lipolysis, protein synthesis stimulation, and glycogen preservation. Also acts on immune cells, chondrocytes, osteoblasts, and satellite cells for tissue repair and remodeling.

Half-life and peak

Subcutaneous half-life approximately 3–4 hours. IV half-life ~20 minutes. Peak serum levels reached 3–6 hours post-injection. IGF-1 elevation persists 20–24 hours. Typically dosed once daily (morning or pre-sleep).

What it is studied for

Growth hormone deficiency (pediatric and adult), body composition, bone density, cardiovascular risk, anti-aging, exercise capacity, wound healing.

Research status

FDA-approved since 1985 (recombinant form). Multiple branded products (Genotropin, Norditropin, Humatrope). Extensive long-term safety data. Controlled substance in many jurisdictions.

Sources

Educational reference only. This page describes what is published about a compound; it is not medical advice, not a recommendation to take anything, and not a dosing guide. Several compounds in this catalog are investigational and are not approved medicines. Talk to a doctor.