BPC-157
Also sold as Body Protective Compound, PL 14736.
- Half-life
- 5 h
- Steady state
- ~1 d
- Class
- Healing
- Category
- Peptide
Published population averages. Steady state is the usual five half-life rule of thumb, not a measurement. See peptide half-life, explained.
Overview
BPC-157 (Body Protection Compound-157) is a pentadecapeptide derived from a protein found in human gastric juice. It has shown significant tissue-healing properties in preclinical studies, particularly for tendons, ligaments, muscles, and the GI tract. It remains investigational with no FDA-approved indication.
How it works
Promotes angiogenesis via VEGF upregulation, modulates nitric oxide pathways (both NOS systems), enhances growth hormone receptor expression, stimulates tendon fibroblast migration, and protects endothelial cells. Acts on the FAK-paxillin pathway crucial for cell migration during wound healing. Also influences dopaminergic and serotonergic systems.
Half-life and peak
Estimated half-life of approximately 4–6 hours based on peptide stability data. No formal human PK studies published. Peak activity estimated at 1–2 hours post-injection. Oral bioavailability has been demonstrated in animal models due to gastric origin stability.
What it is studied for
Tendon and ligament repair, GI mucosal healing (ulcers, IBD models), neuroprotection, muscle regeneration, angiogenesis modulation.
Research status
Preclinical — extensive animal data across 100+ studies. No completed human clinical trials. Several Phase 1/2 trials registered for IBD and wound healing. No regulatory approval.
Sources
- BPC-157 tissue healing review — Journal of Physiology · pubmed.ncbi.nlm.nih.gov
- BPC-157 pharmacological activity — Current Pharmaceutical Design · doi.org
- ClinicalTrials.gov — BPC-157 studies · clinicaltrials.gov
- Stability profile of BPC-157 — J. Pharmacol. · pubmed.ncbi.nlm.nih.gov
Educational reference only. This page describes what is published about a compound; it is not medical advice, not a recommendation to take anything, and not a dosing guide. Several compounds in this catalog are investigational and are not approved medicines. Talk to a doctor.
Guides that cover it
Peptide half-life, explained
Half-life is the number that decides how often something is injected, how long it takes to settle, and how long it lingers after you stop. Here is what it does tell you, and the three things people assume it tells them that it does not.
How to plan and record a peptide cycle
On periods, off periods, and stacks with different frequencies. How to lay a cycle out so that you can tell, six months later, what you were actually running and what it coincided with.